Sounds like a grafting job for The Donald!
I would think "Yes."
We do know that there are some incompatibility issues that exist, and I would think the more complicated we make something, the more likely it could be for one of those to surface.
But, the crabapples that I topworked this year were ornamental crabs grafted to some rootstock. Then I went in on top of that and added a third variety. Those look fine now, but we will see what happens in time.