For a native food plot in Ohio, I would start with giant ragweed and native sunflowers as an edible high-protein screen. It would be planted relatively sparse, but wide. I want the deer to feel secure but not trapped, and I want to cover my approach and exit. Wherever I have a stand, I would plant a strip denser and wider to discourage travel within 20 yards of the tree I'm hunting from.
Inside the plot, I would plant partridge pea, oldfield aster, Jerusalem artichoke, coreopsis, evening primrose, ragweed, goldenrod, pokeweed, tick trefoil, bluebell, wingstem, coneflower, purple poppy mallow, milkweeds, and wild lettuce.
For shrubs, I would plant native plums, hazelnut, sumac, dogwoods, willows, and viburnum, at a rate of about 10-20 shrubs per acre.
This should be a good mix of food and cover, all native, for the deer, insects, and other wildlife. I would only enter once in the summer to manage invasives. We have a problem with cutleaf teasel, Asian honeysuckles, Callery pear, and buckthorn. We also have black medick and nodding thistle, but they don't seem to be a problem, so I wouldn't spend time focusing on them.
Ideally I could spend one day a year on this plot. I would take loppers and a bottle of dyed herbicide with a sponge attached to the top to kill buckthorn, Callery, and honeysuckle. And I would have a sprayer to hit the teasel after lopping off the seed heads. I think I could manage up to about 3 acres a day this way, depending on how persistent the invasives were.