MoJo - I've never used Immunox, so can't answer that one. Read the directions that come with it, or research at a local university web-site / call the extension office of that university. Much good help available. U. of Michigan and MSU are great resources for fruit trees.
As for spraying for the life of the tree - I'd say it depends on what you want from the tree(s). If it's for deer, I've read and been told by experts that the first 5 or 6 years are the most critical for spraying so the tree gets established with a good root system and canopy. If a tree gets pruned & trained correctly, so it gets plenty of sunlight and breeze into the center of the tree, spraying becomes less critical the bigger the tree gets. ( This advice applies to DEER trees ). If you are feeding people, I think more spraying is needed for a longer period / life of the tree. I'd have to defer to commercial apple experts for that info. I'm not growing apples for people / market. If we eat any, we'll take them with some fly speck, blemishes, etc.