I would tend to say the genetics question comes down to whether the variety has any real value and is worth preserving. But that is such a loaded question it is really hard to answer. You can see that in every thread we've ever made about which are the best varieties for wildlife. For everyone that says ______ variety is their best deer apple, there will always be someone chime in how that variety was a disappointment, whether it be an old variety or a modern "disease resistant" variety.
To the extent that you have a the time, money, space, and desire, there is no substitute for doing your homework about what varieties might work for you, choosing which ones to plant, and seeing what happens. And then being willing to replace it or topwork/graft it to something else if it isn't a great apple for you. (or a great pear or a great persimmon or a great chestnut tree or whatever).